Sulforhodamine B and exogenous surfactant effects on alveolar surface tension under acute respiratory distress syndrome conditions

Exogenous surfactant in acute respiratory distress syndrome: more is better.

Pulmonary surfactant is a complex of highly active phospholipids and proteins that cover the alveolar epithelial surface of the lungs [1]. Surfactant is synthesized in the alveolar type-II cells, stored in the lamellar bodies, and secreted to the alveolar space where it undergoes complex changes [2]. The composition of lung surfactant in humans is very constant, although it may change in diseas...

Will exogenous surfactant treat respiratory distress syndrome?

Surfactant medication for acute respiratory distress syndrome.

Background. Patients with acute respiratory distress syndrome (ARDS) have a deficiency of surfactant. Surfactant replacement improves physiologic function in such patients, and preliminary data suggest that it may improve survival. Methods. We conducted a prospective, multicenter, double-blind, randomized, placebo-controlled trial involving 725 patients with sepsis-induced ARDS. Patients were s...

Surfactant treatment for acute respiratory distress syndrome.

OBJECTIVE To determine prospectively the efficacy of surfactant in acute respiratory distress syndrome. STUDY DESIGN Twenty patients, 1 month to 16 years of age, diagnosed with an acute pulmonary disease with severe hypoxaemia (PaO2/FiO2 < 100) (13 with systemic or pulmonary disease and seven with cardiac disease) were treated with one to six doses of 50-200 mg/kg of porcine surfactant admini...

Neonatal Respiratory Distress Syndrome: 40 years of Exogenous Surfactant

On August 9th , 1963, Patrick Bouvier Kennedy, the son of USA President John F. Kennedy and Jacqueline Bouvier, died after 39 hours of life, being born 5 1⁄2 weeks premature. This was not a so severe prematurity, but anyhow he was affected by HMD, and at that time only oxygen was available for neonates with respiratory failure. Of course such death gave a great prompt to the research in this fi...